Second‐Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta‐Analysis
Giannini E, Pasta A, Calabrese F, Labanca S, Marenco S, Pieri G, Torres M, Strazzabosco M. Second‐Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta‐Analysis. Liver International 2024, 45: e16222. PMID: 39720853, PMCID: PMC11669080, DOI: 10.1111/liv.16222.Peer-Reviewed Original ResearchConceptsPrimary biliary cholangitisSecond-line treatmentNetwork meta-analysisObeticholic acid 5Obeticholic acidBiliary cholangitisRelative riskIncomplete response to ursodeoxycholic acidPlacebo-controlled trial of patientsUrsodeoxycholic acidResponse to ursodeoxycholic acidSecond-line therapyIncreased risk of SAEsPlacebo-controlled trialIncidence of pruritusMeta-analysisTrial of patientsPrevent disease progressionRisk of SAEsCompare relative risksComparative efficacyDisease progressionIncreased riskBiochemical responsesSecondary outcomes
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