γ-secretase facilitates retromer-mediated retrograde transport
Takeo Y, Crite M, Mehmood K, DiMaio D. γ-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkTransport of protein cargoRetrograde protein traffickingCation-independent mannose-6-phosphate receptorCellular transmembrane proteinsMannose-6-phosphate receptorAssociation with cargoHuman epithelial cellsBinds retromerRetromer subunitsRetromer cargoRab7-GTPShiga toxinRetrograde transportCultured human epithelial cellsProtein traffickingRetromerCatalytic subunitTransmembrane domainTransmembrane proteinsProtein cargoCellular cargoTarget proteinsFunctional consequencesCholera toxin
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