2025
Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
2021
Imaging extracellular acidification and immune activation in cancer
Hyder F, Coman D. Imaging extracellular acidification and immune activation in cancer. Current Opinion In Biomedical Engineering 2021, 18: 100278. PMID: 33997581, PMCID: PMC8115219, DOI: 10.1016/j.cobme.2021.100278.Peer-Reviewed Original ResearchGene-centric viewMetabolic reprogrammingHostile ecosystemCancer hallmarksHabitat acidificationHost cellsFuture cancer therapyAerobic glycolysisDiverse mechanismsMetabolic interactionsExtracellular acidificationDifferent nutrientsCancer cellsImmune cellsDisease tissuesCellsTumor milieuNutrientsCancer therapyMetabolismRecent evidenceIncidental phenomenonAcidificationReprogrammingOncogene
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